John Cox

Blogs · @wyome

Tagged inflammation · everything

Your Anti-Inflammatory Meds Are Secretly Hurting You

Renowned exercise immunologist David Nieman found that 70% of ultramarathoners use ibuprofen during races, but his research shows it actually worsens outcomes—increasing endotoxemia, systemic inflammation, and kidney dysfunction without reducing muscle soreness compared to runners who skip NSAIDs. Nieman proposes eating blueberries daily for two weeks before a race as an anti-inflammatory alternative, while other experts recommend acetaminophen, proper fueling, caffeine, and mental strategies as safer ways to manage pain without masking the body's warning signals.

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Should you always treat a fever? The symptom that puzzled doctors for millennia

This piece traces fever from a misunderstood ailment—once treated by bloodletting and even mistaken for the disease itself—to its recognition, after germ theory, as a deliberately regulated immune defence that raises core temperature to hamper pathogen replication and boost white blood cell efficiency. It explains the physiology of the hypothalamic "thermostat," why fevers evolved across cold- and warm-blooded animals alike, and why suppressing mild fevers with medication can sometimes backfire, from slower recovery to greater disease transmission when people resume normal activity too soon. It's worth keeping for its nuanced verdict: fever is generally protective and often best left to run its course for 24-48 hours, but becomes dangerous above ~40C or when it masks serious conditions like sepsis or meningitis.

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